Knowles, J.D., Corne, D.W.: Approximating the Nondominated Front Using the Pareto Archived Evolution Strategy. Morgan Kauffman Publishers, San Francisco (1993) ![]() (ed.) Proceedings of the Fifth International Conference on Genetic Algorithms, San Mateo, California, University of Illinois at Urbana-Champaign, pp. In: Proceedings of the Congress on Evolutionary Computation, IEEE Press, Los Alamitos (2003) (accepted for publication)įonseca, C.M., Fleming, P.J.: Genetic algorithms for multiobjective optimization: formulation, discussion and generalization. Kluwer Academic Publishers, New York (2002) ISBN 0-3064-6762-3Ĭoello Coello, C.A., Reyes Sierra, M.: A Coevolutionary Multi-Objective Evolutionary Algorithm. ![]() doi: 10.1038/ Coello, C.A., Van Veldhuizen, D.A., Lamont, G.B.: EvolutionaryAlgorithms for Solving Multi-Objective Problems. Mutations in COL27A1 cause Steel syndrome and suggest a founder mutation effect in the Puerto Rican population. BRCA1 and BRCA2 founder mutations account for 78% of germline carriers among hereditary breast cancer families in Chile. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Genetic diversity in populations across Latin America: implications for population and medical genetic studies. doi: 10.1093/ije/dyl042.īelbin GM, Nieves-Colón MA, Kenny EE, Moreno-Estrada A, Gignoux CR. Cohort profile: the Mexico City Prospective Study. BMI Regression models were adjusted for sex, age, age 2, and ancestry PCs. Panel B displays the change in BMI per BMI PRS standard deviation (SD) using the same color scheme based on 1000 Genomes-based continental ancestry, with the shapes denoting the mean BMI change (circle, triangle, rectangle, dash, and dotted rectangle and vertical bars denoting the 95% confidence interval. The BMI values used in PRS derivation were transformed (RINT by sex, ancestry PCs) and adjusted for age and age 2. The R 2 measures are denoted by a circle (African), triangle (East Asian), rectangle (European), dash (Latino), and dotted rectangle (South Asian), with vertical bars denoting the 95% confidence interval. In panel A, the MCPS PRS accuracy is measured using the incremental R 2 between the BMI PRS and measured BMI (kg/m 2) in UK Biobank individuals, stratified by 1000 Genomes-based continental ancestry (red = African, lime green = East Asian, green = European, blue = Latino, purple = South Asian ). ![]() Our work illustrates the value of genetic studies in diverse populations and provides foundational imputation and allele frequency resources for future genetic studies in Mexico and in the United States, where the Hispanic/Latino population is predominantly of Mexican descent. Using whole-genome sequencing, we developed an imputation reference panel that outperforms existing panels at common variants in individuals with high proportions of central, southern and southeastern Indigenous Mexican ancestry. We estimated ancestry-specific allele frequencies at 142 million genomic variants, with an effective sample size of 91,856 for Indigenous Mexican ancestry at exome variants, all available through a public browser. Indigenous Mexican segments of the genome had lower levels of coding variation but an excess of homozygous loss-of-function variants compared with segments of African and European origin. Most sequenced individuals had admixed Indigenous American, European and African ancestry, with extensive admixture from Indigenous populations in central, southern and southeastern Mexico. We describe high levels of relatedness and substantial heterogeneity in ancestry composition across individuals. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City 1.
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